带有多炎的异性粒状炎及其与蒙特卢卡斯特的关联:基于病例的综述
Grace Alexander1, Steven A Moore2, Petar S Lenert3
1Department of Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Clinical rheumatology
|May 8, 2024
概括
药物诱导的全身性血管炎,特别是带有多炎的eosinophilic granulomatosis (EGPA),与像蒙特卢卡斯特这样的白血素抑制剂有关. 病例表明,在停止服用药物后,EGPA会消失,这表明存在因果关系.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 确定的联系存在于某些药物和疾病之间,如药物诱导的狼和肝炎.
- 与免疫相关的不良事件,包括炎症性多关节炎和肌肉炎,已与检查点抑制剂报告.
- 将药物与全身性血管炎联系起来的数据有限,并且经常受到争议.
研究的目的:
- 为了调查白三烯抑制剂和带有多炎 (EGPA) 的eosinophilic granulomatosis之间的有争议的关联.
- 审查现有的文献,以检查在没有先前使用口服皮质类固醇的情况下使用蒙特卢卡斯特的患者中EGPA的病例.
主要方法:
- 系统的文献综述报告EGPA在服用白血抑制剂的患者中的病例.
- 纳入标准侧重于没有口服皮质类固醇使用史的患者.
- 对24个报告病例的分析与两个新的病例描述相结合.
主要成果:
- 总共有26例与白血抑制剂相关的EGPA病例被确定.
- 患者的平均年龄为43岁,女性占主导地位 (18/26).
- 在大多数情况下,在药物停用后,EGPA类疾病不会复发.
结论:
- 在使用白血抑制剂和eosinophilic EGPA之间存在潜在的因果关系.
- 停止使用白血抑制剂后EGPA的解决支持药物诱导的病因.
- 需要进一步的研究来证实这种联系,并了解潜在的机制.
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