在野外型和脆弱的X综合征模型小鼠中,在皮质时处理和事件相关潜力中,在发育过程中的性别差异
Katilynne Croom1, Jeffrey A Rumschlag2, Michael A Erickson3
1Graduate Neuroscience Program, University of California, Riverside, USA.
Journal of neurodevelopmental disorders
|May 9, 2024
概括
这项研究揭示了在脆弱X综合征 (FXS) 的小鼠模型中,听觉时间处理发展的性别差异,这是自闭症谱系障碍 (ASD) 的原因. 与雄性相比,雌性小鼠表现出明显的过敏反应和更快的成熟.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
背景情况:
- 自闭症谱系障碍 (ASD) 影响美国44名儿童中有1名,男孩更常被诊断为自闭症.
- 听觉时间处理对言语和语言至关重要;缺陷可能解释ASD语言障碍.
- 时间处理中的性别差异可能会导致ASD的语言结果变化.
研究的目的:
- 在脆弱X综合征 (FXS) 的小鼠模型中调查听觉时间处理发展中的性别差异.
- 了解Fmr1基因在特定性别的听觉处理发育轨迹中的作用.
主要方法:
- 在发育过程中比较雄性和雌性野生型 (WT) 和Fmr1淘汰 (KO) 老鼠 (p21,p30,p60).
- 记录的听觉事件相关潜力 (ERP) 和听觉稳定状态响应 (ASSR) 在听觉和额叶皮层.
- 在清醒,自由移动的小鼠中利用了外周螺杆电极.
主要成果:
- 与WT相比,Fmr1 KO小鼠的ERP幅度增强,在成年雌性中增强更大.
- 雌性KO小鼠表现出早期的额叶皮层间隙-ASSR缺陷 (p21),但在p30时显示出WT类处理.
- 在成年雄性或雌性KO小鼠中没有观察到时间处理缺陷.
结论:
- Fmr1 KO小鼠在时间处理和过敏性方面表现出性别特定的发育轨迹.
- 雄性KO小鼠比雌性表现出较慢的时间处理成熟.
- 雌性KO小鼠在发育后期表现出更强烈的过敏反应,可能会影响FXS中的语言,兴奋和焦虑.
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