甲酸代谢物与牙周炎的关联:一个基于人口的研究
Mengyao Bian1, Wenxiang Jiang1, Manting Wang1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
BMC oral health
|May 9, 2024
概括
像MECPP和MEHHP这样的甲酸代谢物与美国成年人牙周炎风险增加有关. 这项研究强调了可能导致这种常见牙疾病的环境因素.
科学领域:
- 环境健康 环境健康
- 口腔卫生流行病学 口腔卫生流行病学
背景情况:
- 广泛接触甲酸盐是一个公共卫生问题.
- 特定的甲酸代谢物和牙周炎之间的联系需要进一步研究.
研究的目的:
- 检查美国成年人中十种甲酸代谢物和牙周炎之间的关联.
- 使用受限立方线分析探索潜在的非线性关系.
主要方法:
- 从NHANES (2009-2014) 中对3402名参与者的横截面分析.
- 使用了加权后勤回归模型.
- 限制的立方线线评估了非线性关联.
主要成果:
- 牙周炎的患病率为42.37%.
- 增加MECPP,MnBP,MEHHP,MiBP,MEOHP和MBzP的水平与牙周炎的更高几率有关.
- 某些甲酸的度升高与牙周炎的几率显著增加有关.
结论:
- 特定的甲酸代谢物与美国成年人群的牙周炎有关.
- 研究结果表明,酸盐可能是导致牙周炎的潜在因素.
相关概念视频
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...