成年早期肺功能的预测因素:基于人口的队列研究
Xian Zhang1,2, Andrew R Gray1, Robert J Hancox1
1Department of Preventive & Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
概括
儿童喘和呼吸道问题降低了成年早期的肺功能,增加了COPD风险. 促进体育活动和健康体重,同时防止吸烟,是肺部健康的关键.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肺功能在成年早期达到顶峰,然后下降.
- 低于最佳的早期成年人肺功能是慢性阻塞性肺病 (COPD) 的危险因素.
- 了解儿童/青少年对肺功能高原的影响对于COPD自然史见解至关重要.
研究的目的:
- 调查儿童/青少年暴露与早期成年人的肺功能之间的关联.
- 在肺功能高原阶段分析FEV1,FVC和FEV1/FVC.
- 确定各种暴露之间的潜在相互作用.
主要方法:
- 基于人口的出生队列中的688名参与者的纵向螺旋计数据.
- 用于重复测量分析的概括估计方程.
- 检查的暴露包括喘,呼吸道过敏反应,吸烟,BMI和身体活动.
主要成果:
- 儿童喘和气道过敏反应与早期成人FEV1和FEV1/FVC的降低有关.
- 18岁或更高早期成年人BMI吸烟与FEV1,FVC和FEV1/FVC降低有关.
- 青少年的体力活动与FEV1和FEV1/FVC积极相关,特别是在男性中.
结论:
- 儿童喘和气道过敏反应预测早期成年人的肺功能较低.
- 针对这些疾病的干预措施可以减轻中晚成人慢性肺炎的风险.
- 优先考虑体育活动,吸烟预防和健康体重对于肺部健康至关重要.
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