COVID-19 治疗方法 为什么不是 ангиотензин受体阻断剂 (ARB)?
1Professor of Pharmacology Retired, MOSC Medical College, Kolenchery, Kerala, India, Corresponding Author.
概括
ангиотензинII (Ang II) 抑制剂,特别是 ангиотензинII受体阻断剂 (ARBs),是有效的COVID-19治疗方法. 通过抵消Ang II过活性的作用,ARB减轻肺损伤并降低死亡率,提供安全和有前途的治疗选择.
科学领域:
- 心血管药理学心血管药理学
- 传染病的发病因子 传染病的发病因子
- COVID-19 治疗方法 治疗方法
背景情况:
- COVID-19与氨酸- ангиотензин- алдостерон系统 (RAAS) 的过度活性有关,其证据是氨酸II (Ang II) 水平升高.
- 病毒诱导的血管酶转化酶-2 (ACE2) 的下调有助于增加Ang II度.
- 高Ang II水平在COVID-19病变发生过程中起着关键作用,导致炎症,免疫刺激和凝血,导致肺损伤.
研究的目的:
- 评估 ангиотензин II (Ang II) 抑制剂作为COVID-19的逻辑治疗策略的潜力.
- 为了比较 ангиотензин转化酶抑制剂 (ACEI) 和 ангиотензин受体阻断剂 (ARB) 在管理COVID-19中的有效性和安全性.
主要方法:
- 对COVID-19中RAAS过活性的现有证据的审查.
- 对ACEI和ARB与Ang II相关的作用机制的分析.
- 对COVID-19中Ang II抑制剂的动物研究和人类观察数据的检查.
主要成果:
- 由于干咳和血管等不良反应较少,ARBs表现出比ACEI更好的安全性.
- 在动物模型中,Ang II 抑制剂已经显示出对病毒诱导的肺损伤的保护作用.
- 人类的观察性研究表明,使用Ang II抑制剂可缩短住院时间和降低死亡率.
结论:
- 血管激素II (Ang II) 抑制剂,特别是ARBs,代表了COVID-19的逻辑和有效的治疗方法.
- 由于其有效性,安全性和对病毒进入或复制的影响最小,ARBs是首选的选择,即使有新兴变异.
- 在有症状的COVID-19患者中常规使用ARB需要认真考虑,以改善临床结果.
更多相关视频
相关概念视频
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
422
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
422
Antihypertensive Drugs: Direct Renin Inhibitors
601
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
601
Antihypertensive Drugs: Angiotensin II Receptor Blockers
715
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
715
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
620
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
620
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
157
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
157
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
155
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
155


