与vibegron,mirabegron和抗胆固醇药物在患有过度活性膀的患者中的真实世界坚持和持久模式的比较分析:一项回顾性索赔研究
Benjamin Chastek1, Adam Carrera2, Christina Landis1
1Optum, Eden Prairie, Minnesota, USA.
Neurourology and urodynamics
|May 9, 2024
概括
与mirabegron和抗胆固醇药物相比,Vibegron在过度活动的膀治疗中表现出更好的坚持性和更长的持续时间. 这项现实世界的研究突出了vibegron的重点.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 现实世界的证据.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 维贝格龙是一种选择性β3-上腺素受体激动剂,已获得FDA批准,用于成年人过度活性膀 (OAB).
- 关于vibegron的坚持和持久性的现实数据对于了解其比较有效性至关重要.
研究的目的:
- 为了比较vibegron与mirabegron的现实世界的坚持和坚持.
- 在OAB患者中,比较vibegron与抗胆固醇药物的真实粘附性和持久性.
主要方法:
- 美国药房索赔数据的回顾性分析 (2021年4月至2022年8月).
- 倾向性得分匹配用于创建vibegron与mirabegron和vibegron与抗胆固醇药物的可比队列.
- 通过覆盖日数比例 (PDC ≥80%) 测量坚持;持久性定义为停药前的几天.
主要成果:
- 维贝格龙患者的PDC平均值明显高于米拉贝格龙 (0.67比0.64) 和抗胆固醇药使用者 (0.67比0.58).
- 与mirabegron (45.1%) 和抗胆固醇药物 (38.5%) 相比,观察到vibegron (49.1%) 的坚持率更高.
- 维贝格伦的持续时间更长:171天与mirabegron (128天) 相比,172天与抗胆药 (91天) 相比.
结论:
- 使用Vibegron与显著改善的坚持有关.
- 与mirabegron和抗胆固醇药物相比,服用vibegron的患者的治疗持续时间更长.
- 这些发现支持vibegron作为OAB的有效现实世界治疗选择.
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