乳糖酶治疗婴儿结肠:随机临床试验的系统审查
Angélica Luciana Nau1, Amanda Santiago Bassan2, Alessandra Bacelar Cezar3
1Division of Pediatric Gastroenterology, Hospital Jaraguá, Jaraguá do Sul, Brazil.
概括
乳糖补充剂在治疗婴儿结肠方面显示出不同的结果,一些研究表明哭泣时间减少,而另一些研究发现没有显著差异. 需要进一步的研究来澄清它的有效性.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 基于证据的医学 基于证据的医学
背景情况:
- 婴儿结肠的特点是健康婴儿过度哭泣,其生理病理不清楚.
- 目前的治疗方法通常集中在胃肠道症状上.
- 乳糖补充剂正在被探索作为一种潜在的针对乳糖消化的治疗方法.
研究的目的:
- 系统地审查随机对照试验 (RCT),评估乳糖补充剂对婴儿的疗效.
- 评估乳糖酶对婴儿哭泣时间和胃肠道症状的影响.
主要方法:
- 来自PubMed,Embase和Cochrane数据库的RCT的系统审查.
- 包括被诊断患有婴儿大肠的6个月以下的婴儿.
- 分析了涉及394名参与者的6项RCT的数据.
主要成果:
- 在六个RCT中,有三项报告说,与安慰剂相比,乳糖补充剂显著减少了哭泣时间.
- 其余三项RCT在乳糖酶组和安慰剂组之间哭泣时间没有显著差异.
- 气呼吸测试显示出不一致的结果,只有一个研究报告了呼出的气水平的显著降低.
结论:
- 乳糖补充剂对婴儿结肠的疗效仍然没有确定性.
- 婴儿结肠的药理方法需要进一步研究.
- 对于未来关于乳糖补充剂的研究,需要标准化的诊断标准和结果措施.
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