抗疟疾药物在口腔平坦菌中的有效性:系统性审查
Rosana Tillero1, José González-Serrano2, Vito Carlo Alberto Caponio2,3
1Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain.
Oral diseases
|May 9, 2024
概括
氧化 (HCQ) 在治疗口腔平坦 (OLP) 方面显示出一些前景,研究表明减少疼痛和改善病变. 然而,需要更严格的试验来确认其对OLP管理的有效性和安全性.
科学领域:
- 口服药是一种口服药.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔平坦 (OLP) 是一种慢性炎症状况,影响口腔粘膜.
- 目前对OLP的治疗选择有局限性,需要探索替代疗法.
研究的目的:
- 系统地评估氧化 (HCQ) 和 (CQ) 治疗OLP的疗效和安全性.
- 综合现有临床研究中关于OLP患者HCQ/CQ的证据.
主要方法:
- 在四个主要数据库中进行了全面的文献搜索.
- 包括的研究是临床试验 (RCT和准实验),调查OLP患者的HCQ/CQ.
- 提取和分析了关于疼痛减轻,临床改善和不良反应的数据.
主要成果:
- 分析了11项涉及390名OLP患者的研究,326人接受HCQ,7人接受CQ.
- 在评估这一结果的五项研究中,HCQ都显示减少了疼痛.
- 报告说,OLP病变和症状有显著改善,24%-100%的人实现了完全/几乎完全的反应.
- 常见的副作用包括视力问题,胃肠道不适和皮肤问题,导致17名患者戒药.
结论:
- 目前关于HCQ作为OLP治疗的证据有限.
- 需要进一步进行高质量的随机对照试验 (RCT).
- 未来的研究应该比较HCQ与局部皮质类固醇的疗效,并评估其对OLP复发率的影响.
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