术内放射治疗的生物效应:乳腺癌患者的组织病理变化和免疫调节
Javier I J Orozco1, Betsy J Valdez1, Chikako Matsuba2
1Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, United States.
Frontiers in immunology
|May 9, 2024
概括
术内辐射疗法 (IORT) 改变了乳腺组织,导致状转质形成,并激活了免疫反应. 这表明IORT可能会在某些乳腺癌中增强免疫性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
背景情况:
- 术内放射治疗 (IORT) 在乳房保护手术 (BCS) 期间提供单次辐射剂量.
- IORT对瘤微环境和免疫反应的生物学影响尚未完全理解.
研究的目的:
- 研究IORT在乳腺组织中诱导的细胞和分子变化.
- 评估IORT对瘤微环境和免疫反应调节的影响.
主要方法:
- 在接受IORT (n=11) 和非IORT (n=11) 的BCS患者的再切割组织上进行了组织病理学评估和RNA测序.
- 患者患有激素受体 (HR) 阳性/HER2 阴性,管道癌 in situ (DCIS) 或早期侵袭性乳腺癌.
主要成果:
- 在IORT标本 (63.6%) 中,仅观察到带有异型的形形质形成症,模仿DCIS.
- IORT与1662个差异表达的基因有关,这些基因富含免疫反应途径 (炎症反应,颗粒细胞和T细胞激活).
- IORT样本显示,正常组织中 γδ T 细胞,树突细胞和单细胞的丰富性增加,以及内在的亡信号传递和对玛辐射的反应.
结论:
- IORT诱导了组织学变化,如状转质形成和与免疫反应和亡相关的分子变化.
- 增加的免疫细胞丰富性表明IORT可能增强乳腺组织的免疫性,可能有利于免疫沙漠瘤.
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