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炎症性肠病和神经退行性疾病之间的双向前性关联:基于纵向研究的系统综述和元分析
Jiahao Zong1,2,3, Yue Yang4, Hui Wang1,2,3
1Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China.
患有炎症性肠病 (IBD) 的人患神经退行性疾病 (如阿尔茨海默氏症和帕金森病) 的风险增加. 这项研究证实了双向的大脑-肠轴关系,建议IBD患者进行主动查.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 以前的研究表明,炎症性肠病 (IBD) 与神经退行性疾病之间存在联系.
- 缺乏IBD与各种神经退行性疾病之间的双向关系的全面总结.
研究的目的:
- 进行纵向研究的元分析,以量化IBD和神经退行性疾病之间的双向前景关联.
- 提供IBD患者发展神经退行性疾病风险的最新估计.
主要方法:
- 在主要数据库 (PubMed,科学网,Embase,PsycINFO,Cochrane图书馆) 进行了系统的文献搜索,直到2023年6月.
- 包括研究IBD和神经退行性疾病之间的关联的纵向研究.
- 使用固定或随机效应模型的元分析被用来合成提取的数据.
主要成果:
- 分析包括27项研究,显示IBD患者患有阿尔茨海默病 (HR=1.35),痴呆症 (HR=1.24),多发性硬化症 (HR=2.07) 和帕金森病 (HR=1.23) 的风险显著增加.
- 在一些研究中,还注意到肌缩性侧面硬化和多重系统缩的风险增加.
- 观察到一种双向关联,在患有多发性硬化症的患者中IBD的发病率更高 (HR=1.87).
结论:
- 这些发现证实了大脑-肠轴内的显著双向关系,突出显示IBD患者多种神经退行性疾病的风险增加.
- 在IBD患者中实施神经退行性疾病查策略可以促进早期诊断和治疗,从而减少整体公共卫生和社会负担.
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