人类大脑磁共振成像研究精神疾病:目前的进展和未来的方向
Jennifer Shi1,2, Shinsuke Koike2,3,4
1Department of Molecular Biology, Princeton University, Princeton, USA.
JMA journal
|May 9, 2024
概括
磁共振成像 (MRI) 通过识别生物标志物来推进精神疾病研究. 然而,技术和方法的局限性仍然存在,需要像日本的Brain/MINDS计划这样的大规模研究来克服这些挑战.
科学领域:
- 神经成像是一种神经成像.
- 精神病学研究 精神病学研究
- 生物标志物发现发现
背景情况:
- 精神疾病的流行需要先进的诊断和治疗策略.
- 磁共振成像 (MRI) 显示出发现病理基础和识别生物标志物的前景.
- 目前的MRI研究面临的局限性是由于在病例控制研究中的技术限制和方法问题.
研究的目的:
- 在精神疾病中审查大脑MRI方法的进展和局限性.
- 探索共享和特定的病理特征的跨境疾病方法.
- 概述健康的大脑发育和衰老的轨迹,以了解疾病的偏差.
主要方法:
- 关于近期精神疾病MRI研究的文献综述.
- 对跨境违规方法的分析.
- 检查发育和衰老的大脑变化.
- 介绍日本的大规模神经成像计划 (Brain/MINDS和Brain/MINDS Beyond).
主要成果:
- 磁力共振成像对理解精神疾病做出了重大贡献,但面临着局限性.
- 跨障碍方法提供了洞察力,但与确定的病理界限作斗争.
- 疾病分层是复杂的,因为疾病内部异质性和不同的进展时间表.
- 大规模,协调的神经成像研究正在出现,以解决当前的局限性.
结论:
- 尽管取得了进展,但使用MRI对精神疾病的确切病理分层仍然是一个挑战.
- 技术和方法上的改进对于推进精神病学研究中的MRI至关重要.
- 像Brain/MINDS这样的协作,大规模的神经成像计划对于未来的突破至关重要.
相关概念视频
Brain Imaging
227
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
227
Magnetic Resonance Imaging
5.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.1K


