管理抗性高血压的方法:一篇综述
Sanjay Mittal1, Peeyush Jain2, Rajat Sharma3
1Clinical and Preventive Cardiology Department, Medanta Hospital, Gurugram, IND.
Cureus
|May 9, 2024
概括
高血压影响了三分之一的印度成年人,耐药高血压影响了2300万. 像SGLT2抑制剂这样的新疗法为这些患者提供了更好的管理和心血管保护.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压 (HTN) 影响了2.34亿印度成年人,其中抗性高血压 (RH) 占10% (2300万).
- 印度目前对HTN的治疗和控制率很低,平均分别为30%和15%.
- 现有的药理管理遵循一个逐步的方法,以ACEI/ARBs,CCBs,利尿剂和螺旋乳升级治疗.
研究的目的:
- 审查目前印度高血压的治疗策略.
- 探索-葡萄糖共传输体-2 抑制剂 (SGLT2i) 在治疗耐性高血压方面的潜在作用.
- 强调患者教育和预防失控高血压的预防措施的重要性.
主要方法:
- 对印度高血压管理当前药理指南的审查.
- 讨论支持SGLT2抑制剂在耐性高血压中的证据.
- 强调个性化治疗和以患者为中心的方法.
主要成果:
- 标准的逐步治疗包括优化ACD组合,其次是螺旋,β-阻断剂和α-阻断剂/血管扩张剂.
- SGLT2抑制剂在管理RH方面表现有前途,提供脏和心血管保护以及死亡率的好处.
- SGLT2 抑制剂可以独立于剂量和其他抗高血压药物降低血压.
结论:
- 个性化,逐步的药理方法对于治疗耐性高血压至关重要.
- SGLT2 抑制剂对抗性高血压是一种有前途的治疗选择,可以改善血压控制并提供心脏保护性益处.
- 患者教育,血压监测和遵守是成功管理和预防高血压的关键.
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