上腺皮癌患者的生存名录和风险分类系统:基于SEER数据库和中国外部验证的研究
Zhizhou Li1, Maoyu Wang1, Wei Gang2
1Department of Urology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Translational andrology and urology
|May 9, 2024
概括
这项研究开发了一个名谱和风险系统,用于预测上腺皮质癌 (ACC) 患者的整体生存期 (OS). 该模型准确识别高风险个体,有助于对这种罕见的癌症的治疗决策.
科学领域:
- 在瘤学瘤学.
- 癌症预后 癌症预后
- 医疗信息学 医疗信息学
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的,高度侵入性的恶性瘤,没有可靠的预后指标.
- 准确预测整体存活率 (OS) 对患者管理和治疗规划至关重要.
研究的目的:
- 开发和验证一种名谱和风险分类系统,用于预测ACC患者的1年,3年和5年的生存期.
- 确定影响ACC预后的关键临床病理因素.
主要方法:
- 利用SEER数据库和外部验证队列进行培训和测试.
- 进行单变量和多变量考克斯回归分析以确定预后因素.
- 开发了一种包含年龄,T,N,M和化疗史的名录;使用C指数,ROC和DCA进行验证.
主要成果:
- 基于五个因素的诺米图表显示出显著的预测能力 (C指数>0.70,AUC>0.70).
- 决策曲线分析证实了名图的临床实用性.
- 在低风险 (70个月) 和高风险 (10个月) 组之间,中位 OS 显著不同.
结论:
- 一个经过验证的名谱和风险分层系统可以预测上皮癌患者的OS.
- 这些工具为患者咨询和ACC管理中的临床决策提供了宝贵的支持.
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