膀的简要生理学和病理生理学
Jörgen Quaghebeur1, Mark Bush2, Dmitry Shkarupa3
1Faculty of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium.
Annals of translational medicine
|May 9, 2024
概括
综合理论认为,女性尿失禁和膀过活是由于骨盆带疲弱而不是膀问题引起的. 带修复为这些常见疾病提供了潜在的治疗方法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 妇科 妇科医生 妇科
- 盆地底疾病 盆地底疾病
背景情况:
- 主流观点认为,过度活性膀 (OAB) 病原因是未知的原因,没有确定的治疗方法.
- 综合理论 (IT) 认为膀控制是一种二元皮质-外周系统,挑战现有的范式.
- 女性尿失禁 (UI) 和OAB症状与外周结构,特别是骨盆带和阴道支有关.
研究的目的:
- 审查支持女性尿失禁 (IT) 综合理论的实验作品.
- 阐明IT对过度活性膀 (OAB) 和尿失禁的病原性解释.
- 通过针对带支持的治疗来探索治愈的潜力.
主要方法:
- 对女性尿失禁综合理论相关的实验性出版物的综述.
- 对IT提出的膀控制机制的分析,涉及皮质和外围反循环.
- 考察了原缺乏,分娩和衰老在带衰弱和UI中的作用.
主要成果:
- 该IT将UI和OAB归因于骨盆带 (阴道,子宫) 和阴道支的削弱,主要是由于原缺乏.
- 软弱的带会损害尿道关闭 (压力失禁),疏散 (保留) 和阴道支,导致尿延伸受体过早发射 (冲动失禁).
- 旨在加强这些带的治疗方法在治疗或改善压力尿失禁 (SUI),OAB和排空功能障碍方面表现有前途.
结论:
- 膀控制是依赖于带和阴道完整性的外周机制,由皮质输入调节.
- 将OAB重新构想为"过度活跃"而不是"过度活跃"与IT一致,并表明治愈的可能性更高.
- 该IT为各种形式的女性尿失禁和膀过活提供了统一的解释,强调带修复作为治疗目标.
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