从猫身上分离出来的乳酸细菌的特征和潜在的降脂作用
Shukun Liang1,2, Yanhua Kang2, Ya Zhao1
1Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.
Frontiers in microbiology
|May 9, 2024
概括
从猫便中分离出来的三种乳酸细菌菌株显示出降低胆固醇和减少小鼠肥胖和炎症的潜力. 这些益生菌显示出有前途的降脂效果和肠道微生物群调节.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 动物科学动物科学
背景情况:
- 乳酸细菌 (LAB) 以其健康益处而闻名,包括在管理脂质代谢和炎症方面的潜在作用.
- 来自动物来源的新型LAB菌株的特征化可以为动物健康应用产生有益的益生菌.
- 肥胖和相关的代谢障碍是动物健康的重大问题,需要有效的干预措施.
研究的目的:
- 从健康的成年猫便中分离和特征化新型乳酸细菌菌株.
- 评估选择的LAB菌株的体外和体内降脂和抗炎作用.
- 在小鼠模型中研究这些LAB菌株对肠道微生物群组成的影响.
主要方法:
- 从85个猫便样本中分离和选221种乳酸细菌菌株.
- 对胆固醇降解,胆汁盐耐受性和抗酸性有希望的菌株的表征.
- 在体内进行的一项研究,涉及向小鼠食高脂肪饮食 (HFD),并补充精选的LAB菌株 (Lactobacillus plantarum L-27-2,Pediococcus lactis L-14-1,Enterococcus faecium),并评估代谢参数和肠道微生物群.
主要成果:
- 三种LAB菌株 (L. plantarum L-27-2,P. lactis L-14-1,E. faecium) 显示出显著的胆固醇降解 (>20%) 和抗病原体活性.
- 在实体中,这些LAB菌株的使用减少了体重增加,减轻了脂肪组织的病理变化,并减少了HFD养小鼠的腹部脂肪积累.
- 特定菌株调节了血清脂质概况 (甘油三,HDL-C) 和减少了炎症性细胞因子 (IL-6),以及肠道微生物群组成的显著变化 (例如,减少了Bacteroides,增加了Myxococcus).
结论:
- 从猫中分离出来的新型乳酸细菌菌株具有显著的体外和体外降脂和抗炎性质.
- 这些已识别的LAB菌株,特别是L. plantarum L-27-2和P. lactis L-14-1,显示出作为治疗动物肥胖和炎症的益生菌的潜力.
- 这项研究强调了来自猫的LAB在调节肠道微生物群和改善代谢健康方面的潜力.
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