相关实验视频
Updated: Jul 16, 2026

09:52
An Implantable System For Chronic In Vivo Electromyography
Published on: April 21, 2020
10.7K
对左侧与右侧内在喉肌肉的转录组分析与内心神经关联
Angela M Kemfack1, Ignacio Hernandez-Morato1,2, Yalda Moayedi1,3,4
1The Center for Voice and Swallowing, Department of Otolaryngology-Head & Neck Surgery, Columbia University Irving Medical Center, New York, New York, U.S.A.
The Laryngoscope
|May 9, 2024
概括
左侧声带可能源于喉肌肉中的基因表达差异. 这项研究发现左侧和右侧内在喉肌肉之间存在明显的基因特征,这表明横向性的遗传基础.
科学领域:
- 分子生物学分子生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 反复发生的喉神经损伤往往导致左侧声带.
- 这种横向性通常归因于神经长度,但遗传因素也可能起作用.
- 研究内在喉肌肉 (ILM) 的基因表达可以揭示这种不对称性背后的机制.
研究的目的:
- 分析大鼠ILM的转录组概况,以确定左右基因表达差异.
- 调查ILM中不对称的基因表达是否有助于声带的侧向性.
- 确定特定的基因和途径参与ILM神经肌肉功能和横向性.
主要方法:
- 从老鼠的左侧和右侧ILM (后部甲状腺,侧部甲状腺,中部甲状腺) 中提取RNA.
- 高通量RNA测序在88个不同年龄,性别和肌肉类型的样本上进行.
- 综合生物信息学分析比较左右ILM基因表达模式.
主要成果:
- 在左侧和右侧的ILM之间,共识了774个差异表达的基因.
- 基因表达的差异具体取决于年龄,性别和肌肉类型.
- 丰富分析揭示了与神经/肌肉生理学,免疫反应和激素控制相关的基因的左右不对称性.
结论:
- 生物信息学分析证实左侧和右侧ILM之间的转录组配置不同.
- 这项研究确定了有助于ILM横向性的潜在基因标.
- 研究结果表明,观察到的左侧声带的患病率存在遗传基础.
相关概念视频
Assessment of Airway, Skin Color, and Use of Accessory Muscles
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
Introduction
The initial evaluation of a patient's respiratory system...
Muscles for Facial Expressions
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
Muscles of the Anterior Neck
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
Cranial Nerves: Types Part II
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Larynx
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Lateralization
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

