酒精里程碑和内化,外化和执行功能:纵向和多基因分数协会
Sarah E Paul1, David A A Baranger1, Emma C Johnson2
1Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Psychological medicine
|May 9, 2024
概括
诸如外部化和内部化症状之类的行为问题可以预测未来的酒精问题和发展为酒精使用障碍 (AUD). 酒精使用也增加了以后精神健康问题的风险,显示出双向联系.
科学领域:
- 成研究研究成研究
- 行为遗传学行为遗传学
- 精神病学是一个精神病学.
背景情况:
- 酒精使用与行为表型 (例如冲动性,负面影响,执行功能) 之间的关系是已知的,但方向性和共同的遗传因素尚不清楚.
- 了解这些动态对于开发有效的酒精使用障碍 (AUD) 预防和干预策略至关重要.
研究的目的:
- 调查酒精参与中的过渡,行为表型和遗传风险之间的纵向关联.
- 澄清酒精使用障碍发展中的定向性和共同遗传责任.
主要方法:
- 利用了关于酒遗传学的合作研究 (n=3681,年龄11-36) 的数据.
- 评估酒精过渡 (第一次饮酒,中毒,AUD症状/诊断),内化/外化表型和执行功能 (EF).
- 计算了酒精和行为表型的多基因分数 (PGS),并使用考克斯模型来分析关联.
主要成果:
- 外向化表型预测了未来的酒精开始和问题;内部化表型预测了严重AUD的进展.
- 酒精开始和AUD与后来的抑郁症状和自杀念头的风险增加有关.
- 酒精消费和问题性使用的多基因评分分别与酒精过渡和自杀念头的风险增加有关.
结论:
- 成脆弱性的行为标志物可以在酒精参与之前和之后出现,表明动态的,双向的关系.
- 这些发现强调了行为和成发展之间的复杂相互作用.
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