全肠道克罗恩囊 [Eliakim] 评分可靠性和对活跃克罗恩病变化的反应性
Offir Ukashi1,2, Adi Lahat1,2, Bella Ungar1,2
1Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.
伊利亚基姆评分 (ES) 可靠地评估使用囊内镜在活跃克罗恩病 (CD) 中的全肠炎症. 与易斯评分 (LS) 相比,ES显示了随着时间的推移对治疗变化的更好反应.
科学领域:
- 胃肠病学和肝病学
- 炎症性肠道疾病研究研究
- 医学成像和内镜检查
背景情况:
- 全肠道囊内镜 (PillCam 克罗恩囊 [PCC]) 已建立用于诊断和监测克罗恩病 (CD).
- 伊利亚基姆评分 (ES) 已经证明了可靠性和与易斯评分 (LS) 和静止性CD的炎症生物标志物的相关性.
- 在主动CD中ES的性能和响应性需要进一步研究.
研究的目的:
- 评估伊利亚基姆评分 (ES) 在评估活跃克罗恩病 (CD) 患者全肠粘膜炎症的表现.
- 评估ES对CD患者52周内临床和生化变化的反应能力.
- 为了将ES的响应能力与活跃CD中的易斯得分 (LS) 的响应能力进行比较.
主要方法:
- 74名患有CD发病的患者的前性随访生物药物.
- 在基线,14周和52周对临床访问,生物标志物 (克罗恩病活性指数[CDAI],C反应蛋白[CRP],便calprotectin[FC]) 和囊内镜 (PCC) 的评估.
- 两个独立的读数器计算LS和ES,使用类内相关性 (ICC) 评估评价者之间的可靠性;使用斯皮尔曼和重复测量相关性 (RMC) 进行的相关性分析.
主要成果:
- 对于LS和ES的高互利率协议 (ICC:分别为0.872和0.925).
- 便calprotectin (FC) 和ES (r=0.509) 与FC和LS (r=0.467) 之间的可比基线相关性.
- 重复措施相关性显示ES对CRP和FC的响应性比LS更高,ES与CDAI的相关性比LS更好.
结论:
- 伊利亚基姆评分 (ES) 是通过囊内镜评估活跃克罗恩病 (CD) 中全肠粘膜炎症的可靠工具.
- 与易斯分数 (LS) 相比,ES显示出与临床和生化变化随时间的推移相对应的潜在反应能力.
- 在CD中,ES可以提供更动态的疾病活动和治疗反应评估.
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