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相关概念视频

Allergic Reactions02:06

Allergic Reactions

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Overview
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
277
Allergic Drug Reactions01:27

Allergic Drug Reactions

838
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
838
Hypersensitivities01:30

Hypersensitivities

615
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Cross-reactivity00:42

Cross-reactivity

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Antibody Structure01:10

Antibody Structure

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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相关实验视频

Updated: Jun 26, 2025

Basophil Activation Test for Allergy Diagnosis
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Basophil Activation Test for Allergy Diagnosis

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药片过敏原免疫疗法:过敏反应问题

Giorgio Ciprandi1, Matteo Naso2, Maria Angela Tosca2

  • 1Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy; gio.cip@libero.it.

Allergologia et immunopathologia
|May 9, 2024
PubMed
概括

对过敏性鼻炎的药片过敏原免疫疗法 (T-AIT) 通常是安全的,特别是在儿童中,报告了罕见的过敏反应病例. 没有死亡事件发生,突出T-AITIT.

科学领域:

  • 过敏和免疫学 过敏和免疫学
  • 儿科过敏 儿科过敏
  • 药物监督 药物监督 药物监督

背景情况:

  • 平板电脑过敏原免疫疗法 (T-AIT) 在草花粉引起的过敏性鼻炎中已经存在了15年.
  • 广泛的数据支持过敏原免疫疗法 (AIT) 的有效性和安全性,在儿童中具有显著的安全性.
  • 虽然通常会引起轻微的局部反应,但像过敏反应这样的全身反应是T-AIT的一个问题.

研究的目的:

  • 调查与T-AIT相关的过敏反应的发生率和特征.
  • 评估T-AIT的整体安全性,特别是在儿科患者中.
  • 审查T-AIT后报告的过敏反应病例的文献.

主要方法:

  • 进行了文献搜索,以确定因T-AIT引起的过敏反应病例报告.
  • 分析报告的病例,重点关注过敏原类型,患者人口统计和结果.
  • 审查安全建议和T-AIT不良事件的趋势.

主要成果:

  • 在文献中发现了9例对T-AIT过敏反应的病例.
  • 所有报告的过敏反应都与草花粉提取物有关.
  • 没有报告任何死亡事故,这强调了T-AIT的普遍有利的安全性.
关键词:
成年人成年人成年人成年人成年人过敏原免疫疗法 免疫疗法过敏反应是一种过敏反应.孩子们的孩子们的孩子们的孩子们.在安全方面,安全是安全的.药片 药片 是 一种药片.

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  • 近年来,由于T-AIT而没有报告过敏反应.

    • 结论:

    • T-AIT显示出相当大的安全性,没有报告过敏反应导致的死亡.
    • 建议仔细监测,特别是在儿科患者中,初始剂量在受控的医疗环境中给予.
    • 虽然草花粉T-AIT与罕见的过敏反应有关,但整体趋势表明安全性得到改善,报告的严重反应减少.