通过使用DOE的飞形成药物递送系统改善了famotidine的胃停留时间
Rajalakshmi Munusamy1, Sangeetha Shanmugasundharam1
1Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Kattankulathur, India.
概括
这项研究开发了一种新型的famotidine飞配方,使用瓜尔和藻酸盐,提高GERD治疗的口服生物可用性和胃停留时间. 优化的配方证明了长时间的胃保留和有效的酸性反流预防.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 胃食道逆流性疾病 (GERD) 和胃需要有效的治疗来控制酸分泌和预防逆流.
- 提高具有狭窄吸收窗口的药物的口服生物可用性是制药开发中的一个挑战.
- 提高胃停留时间 (GRT) 是提高药物吸收和疗效的关键策略.
研究的目的:
- 为了研究作为抗逆流配方的famotidine的飞艇形成悬浮.
- 通过增加胃停留时间 (GRT) 来增强口服 famotidine 的生物可用性.
- 通过有效的制剂来预防胃食道逆流病 (GERD).
主要方法:
- 评估各种漂浮形成剂,包括Tragacanth (TG), guar (GG) 和含酸 (SA) 的桑坦 (XG).
- 使用32个完全因数设计,以GG和SA作为独立变量来优化配方.
- 对子的表面粘度,体外药物释放和体内浮动行为进行评估,以优化配方.
主要成果:
- 优化的配方 (F6) 呈现出理想的重,可延长漂浮时间和改善表面粘度.
- 观察到12小时后显著的famotidine释放,使用数学模型分析药物释放动力学.
- 该配方在加速条件下表现出令人满意的稳定性,并保持在子胃中漂浮超过12小时.
结论:
- 开发的famotidine飞配方通过增加GRT和预防酸倒流来提高生物可用性.
- GG和SA的组合有效地创建了一个浮动层,在胃区域保留famotidine.
- 该配方通过减少酸分泌来治疗胃和GERD有希望.
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