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膀癌的肠道巴西卢斯卡尔梅特-盖林可以预防COVID-19吗?

Anastasia MacDonald¹, Lexia Bao², Vahid Mehrnoush³

¹Department of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON. anamacdonald@nosm.ca.

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

|May 9, 2024

概括

无论是静脉BCG治疗还是婴儿BCG免疫,都与非肌肉侵入性膀癌患者的COVID-19感染率无关. 这项研究发现,BCG病史与COVID-19发病率或严重程度之间没有相关性.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

卡尔梅特-盖林杆菌 (BCG) 疫苗用于结核病的预防和膀癌的静脉内治疗.
由于其已知的免疫调节作用,BCG对包括COVID-19在内的其他感染的潜在影响一直是人们感兴趣的主题.

研究的目的:

调查BCG注射和婴儿BCG免疫接种史以及COVID-19感染的发病率和严重程度之间的相关性.
确定BCG暴露是否影响非肌肉侵入性膀癌 (NMIBC) 患者的SARS-CoV-2感染的易感性或临床结果.

主要方法:

在两个加拿大中心对被诊断患有高风险NMIBC的患者进行了回顾性数据收集.
数据包括患者人口统计数据,静脉BCG治疗史,婴儿BCG疫苗接种状态和COVID-19感染状态,包括住院和死亡率.

主要成果:

该研究包括348名患者 (188名来自安大略省,160名来自不列颠哥伦比亚省).
COVID-19影响了15%的患者队列.
从统计学上来说,在BCG或婴儿BCG免疫接种史和COVID-19感染的发生率或严重程度之间没有显著的相关性.

结论:

经过肠道BCG治疗或婴儿BCG疫苗接种的病史并没有改变感染COVID-19的可能性.
无论是通过膀癌治疗还是儿童免疫接种,BCG暴露对于这个NMIBC患者组的COVID-19结果并不是一个显著的因素.

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