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相关概念视频

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Chronic Pharyngitis01:23

Chronic Pharyngitis

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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慢性 Prurigo 是一个慢性 Prurigo.

Julia Thünemann1, Svenja Müller2, Kerstin Steinbrink1

  • 1Department of Dermatology and Competence Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|May 9, 2024
PubMed
概括
此摘要是机器生成的。

慢性 (CPG) 是一种引起强烈和病变的皮肤疾病. 像Dupilumab这样的新疗法提供了希望,与临床试验中的其他先进治疗方法一起,为更好的患者结果提供了希望.

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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
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相关实验视频

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
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科学领域:

  • 皮肤病学 皮肤病学
  • 神经免疫学 神经免疫学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 慢性 (CPG) 是一种神经炎症性皮肤疾病,由持续的 (>6周),病变和痕定义.
  • CPG显著影响患者的生活质量和精神健康.
  • 慢性结节性 (CNPG) 是最常见的CPG亚型.

研究的目的:

  • 为了提供CPG病理生理学的概述.
  • 审查CPG目前和新兴的治疗选择.
  • 为了突出CPG处理的最新进展.

主要方法:

  • 对CGG的临床特征和疾病负担的审查.
  • 检查CPG背后的病理生理机制.
  • 对CPG的已批准和正在研究的治疗方法的分析.

主要成果:

  • 杜皮卢马布是第一个经EMA和FDA批准的治疗中度至重度CNPG的疗法.
  • 一些生物药物 (尼莫利祖马布,维克萨雷利马布,巴佐尔沃利马布),JAK抑制剂 (波沃西提尼布,阿布罗西提尼布) 和阿片类调节剂 (纳尔布芬) 正在研究中.
  • 目前正在进行的II期和III期试验正在评估这些新型药物.

结论:

  • 在了解CPG病理生理学方面取得了重大进展.
  • 新的向疗法正在出现,为改善CPG管理提供了潜力.
  • 杜皮卢马布代表了一项突破,预计将有更多的治疗选择.