使用可摄入传感器启用暴露前预防预防预防艾滋病毒感染的人员的用户体验:跨部分调查研究
Sara Browne1,2, Anya Umlauf3, David J Moore3
1Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, United States.
JMIR mHealth and uHealth
|May 9, 2024
概括
用于艾滋病毒暴露前预防 (PrEP) 的可摄入传感器 (IS) 的用户体验是积极的. 更高的自我效能与更好的用户体验相关,而抑郁症状和睡眠不足影响了感知效用和整体体验.
科学领域:
- 数字健康数字健康
- 预防艾滋病毒 预防艾滋病毒
- 药物治疗的坚持 药物治疗的坚持
背景情况:
- 数字健康技术的成功取决于用户的接受.
- 用户体验 (UX) 对于评估新医疗技术至关重要.
研究的目的:
- 评估数字健康系统的用户体验 (UX) 具有可摄入传感器 (ISs) 用于口服预暴露预防 (PrEP) 遵守.
- 分析与积极或负面用户体验相关的基线参与者特征.
主要方法:
- 对使用IS-enabled PrEP (IS-Truvada) 的HIV阴性成年人的前性研究.
- 收集的基线数据:人口统计,毒理学,睡眠质量,自我有效性,艾滋病毒的感知风险和抑郁症状.
- 管理了27个问题的用户体验问卷,评估了整体体验,易用性,未来使用意图和感知到的实用性.
主要成果:
- 超过75%的参与者报告了整体用户体验,易用性和感知的实用性.
- 更高的自我效率与更好的总体用户体验得分和所有子得分有显著的关联.
- 增加的抑郁症状与更高的感知效用相关;睡眠不足与更糟糕的整体体验有关.
结论:
- 具有可摄入PrEP传感器的数字健康系统展示了积极的用户体验.
- 自我有效性,抑郁症状和睡眠质量是影响数字健康遵守工具用户体验的关键因素.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒预防艾滋病毒 预防艾滋病毒性传播疾病 (STD) 是一种性传播疾病.这就是STI STI.这是一个UX UX.坚持性 坚持性符合合规性的合规性是什么毒品 毒品 毒品 是一种药物.药物 药物 药物 药物 药物 药物可摄入的传感器药物治疗 药物治疗药物治疗的坚持 药物治疗的坚持药物 药物 药物 药物通过口腔的口腔口腔.药物制造业的制药公司制药公司的药品.药品制品制品制品制品制品制品制品制品药品制药公司 药品制药公司药房 药房 药房 药房 药房药理学 药理学 药理学 药理学 药理学药物治疗药物治疗药房 药房 药房 药房预防 预防 预防预防 预防 预防 预防传感器 传感器 传感器 传感器传感器 传感器 传感器性传播性传播性传播这是一种性传播的疾病.有性传播疾病的性病.性传播感染性传播感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性用户体验用户体验.
相关概念视频
01:15Non-Oral Extravascular Drug Absorption Routes
214
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
214
01:17Drug Absorption: Overview
580
The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...
580
01:18Drug Delivery: Enteral Route
422
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
422
01:24Factors Influencing Drug Absorption: Presystemic Elimination
212
The pharmacokinetic journey of oral drugs begins with a crucial first pass through the hepatic portal system, called the first-pass effect. This first pass significantly impacts bioavailability — the proportion of a drug that enters systemic circulation and is available for therapeutic action. The primary route sees the drug absorbed by intestinal membranes and then shunted to the liver via the hepatic portal vein. Here, pre-systemic elimination occurs as drugs face metabolism or biliary...
212
01:09Methods for Studying Drug Absorption: In situ
227
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
227
01:26Drug Administration and Therapy Phases: Overview
451
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
451