低强度前庭噪声刺激改善了渐进性超核性麻的姿势症状
Max Wuehr1, Daniela Peto2,3, Urban M Fietzek3,4,5
1German Center for Vertigo and Balance Disorders (DSGZ), LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. max.wuehr@med.uni-muenchen.de.
Journal of neurology
|May 9, 2024
概括
噪音动前庭刺激 (nGVS) 减少了超过一半的渐进性上核麻 (PSP) 患者的身体摇摆,表明治疗姿势不稳定的潜力.
科学领域:
- 神经科学是一个神经科学.
- 静脉系统研究研究
- 临床神经学 临床神经学
背景情况:
- 渐进性上核性麻 (PSP) 导致与异常的前体脊柱反射相关的残疾姿势失衡.
- 低强度噪音动前庭刺激 (nGVS) 是一种非侵入性方法,可以改善前庭功能并减少失衡.
- 人们认为GGVS通过随机共振 (SR) 起作用,通过噪音刺激增强感官处理.
研究的目的:
- 研究 nGVS对可能和tau-PET阳性PSP患者的姿势不稳定性的治疗效果.
- 在16名PSP患者的队列中评估 nGVS对身体摇摆的影响.
主要方法:
- 检查了GVS对身体摇摆的影响 (0-0.7mA),使用闭眼姿势学.
- 评估了钟形响应曲线,表明SR,在中间GVS强度时最大的摇摆减少.
- 将SR曲线模型与个体患者数据相匹配,并使用专家评价者的判断来确认SR反应.
主要成果:
- 在9名患者中 (56%) 观察到与SR一致的 nGVS诱导的身体摇摆减少,最佳改善率为31%.
- 在50%的患者中,GVS的改善超过了临床上重要的最小差异,达到34%的摇摆减轻.
- 这些发现表明,在很大一部分PSP队列中,SR效应很强.
结论:
- 非侵入性GVS证明了临床相关的减轻身体摇摆,支持其在增强前庭感觉运动通路中的作用.
- 在PSP患者中,GGVS似乎是一种耐受良好的治疗策略,可以改善PSP患者的姿势症状.
- 至少有一半被评估的PSP患者表现出与随机共振相一致的改善.
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