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Polymer Microarrays for High Throughput Discovery of Biomaterials
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克尔塞加载的聚合物溶解微阵列贴片:制造,表征和评估.

Qonita Kurnia Anjani1,2, Natalia Moreno-Castellanos3, Masoud Adhami1

  • 1School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7BL, UK.

Drug delivery and translational research
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PubMed
概括

这项研究开发了新的素载微阵列贴片 (MAPs),以改善伤口愈合. 这些Soluplus®增强的MAP有效地提供奎尔素,显示抗炎性质和生物相容性.

关键词:
细胞的增殖细胞的增殖.溶解微阵列贴片的方法炎症活动的炎症活动.奎尔丁 (Quercetin) 是一种青素.

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科学领域:

  • 药理学和药物输送 药理学和药物输送
  • 生物材料科学 生物材料科学
  • 皮肤病学和伤口愈合治疗

背景情况:

  • 奎尔因通过减少纤维化和痕形成,显示出治疗伤口的潜力.
  • 氨酸溶解度差限制了生物可用性,需要高剂量才能产生治疗效果.
  • 需要新的药物输送系统来增强奎尔塞丁的伤口愈合效率.

研究的目的:

  • 为改善伤口愈合开发和描述含有素的微阵列补丁 (MAPs).
  • 评估使用Soluplus®的MAP的可溶性增强和药物负载能力.
  • 评估开发的MAPs的体外皮肤传递,抗炎性质和生物相容性.

主要方法:

  • 使用可溶性增强策略制造含奎尔丁的MAP,包括Soluplus®.
  • 评估MAP的机械性能和插入深度到切割的猪皮.
  • 在24小时内使用全厚新生猪皮肤进行体外皮肤透研究.
  • 用人类角质细胞细胞对抗炎症活性和细胞毒性试验的评估.

主要成果:

  • MAP表现出良好的机械强度和皮肤插入深度 (650微米).
  • 用Soluplus®增强的配方实现了高药载荷 (2.5 mg/贴片) 和快速溶解 (<1小时).
  • 在24小时内,MAPs证明了超过80%的氨酸在皮肤层中的传递效率,具有显著的抗炎作用和良好的细胞生物相容性.

结论:

  • 富含奎尔素的MAP,特别是那些用Soluplus®增强的MAP,为伤口愈合提供了一个有前途的策略.
  • 这种新型的输送系统克服了奎尔素的溶解性限制,提高了生物可用性和治疗潜力.
  • 开发的MAP显示了伤口愈合和抗炎应用的潜力,并提高了安全性和有效性.