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多发性硬化和COVID-19:中国北部的一项调查

Qian Guo¹, Tianwei Wang², Yusen Huang¹

¹Department of Neurology, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130000, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 9, 2024

概括

患有多发性硬化症 (MS) 和较短的疾病过程的患者面临更高的SARS-CoV-2感染风险. 晚年与增加的残疾有关,强调在疫情期间谨慎使用某些疗法.

科学领域:

神经学神经学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

关于中国多发性硬化症 (pwMS) 患者中严重急性呼吸系统综合征冠状病毒2型 (SARS-CoV-2) 感染的数据有限.
了解2019年新冠肺炎 (COVID-19) 疫情对中国北部 pwMS 的影响至关重要.

研究的目的:

为了调查中国北部 pwMS 中的COVID-19 的表现.
评估SARS-CoV-2感染对多发性硬化症预后的影响.

主要方法:

一项采用在线问卷和电话采访的横截面研究.
分析中国北部pwMS的临床数据,分析COVID-19大流行期间的SARS-CoV-2感染情况.

主要成果:

在164个pwMS中,83.5%感染了SARS-CoV-2. 较短的疾病持续时间与更高的感染风险相关 (P=0.046),而年龄较大与行为症状恶化有关 (P=0.008).
疾病修饰疗法 (DMT) 和疫苗接种状态没有显著影响感染易感性或预后.
14.6%的感染患者的病情恶化,5.1%的患者复发了MS.

结论:

疾病持续时间较短和年龄较大是SARS-CoV-2感染的风险因素和pwMS的不良结果.
疾病修饰疗法 (DMT) 似乎是安全的和必要的pwMS在疫情期间.
在COVID-19大流行期间,建议在pwMS中使用B细胞消耗剂时谨慎使用.

关键词:

新冠病毒疾病2019年疾病的发展过程.改变疾病的疗法.多发性硬化症是多发性硬化症.严重急性呼吸道综合征冠状病毒-2型

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