使用基因组和双胞胎/收养方法,内部化精神病理和相关的自我报告措施之间存在强烈的遗传相关性的证据
Daniel E Gustavson1, Elisa F Stern1, Chandra A Reynolds1
1Institute for Behavioral Genetics, University of Colorado Boulder.
Journal of psychopathology and clinical science
|May 9, 2024
概括
抑郁和焦虑等内化障碍背后的遗传和环境因素显示出显著的重叠. 虽然诊断和特征测量高度相关,但诊断存在独特的遗传影响.
科学领域:
- 精神病学是一个精神病学.
- 行为遗传学 行为遗传学
- 量化心理学 量化心理学
背景情况:
- 内化构造包括共享的情绪和焦虑障碍的遗传和环境风险.
- 现有的研究确立了诸如主要抑郁症 (MDD) 和泛性焦虑症 (GAD) 等诊断中的内化因素.
- 自我报告的特征 (神经症,担忧,反) 经常被整合,但它们与诊断因素的精确重叠并未得到充分测试.
研究的目的:
- 检查内部化诊断因素和自我报告的内部化特征措施之间的遗传和环境重叠.
- 为了验证诊断和特征措施捕获相同的潜在风险因素内化精神病理的假设.
主要方法:
- 用全基因组关联研究 (GWAS) 进行基因组结构方程建模,以内化诊断和特征.
- 在组合双胞胎/收养样本中进行潜在因子分析,以评估遗传和环境影响.
- 融合的方法来量化诊断和基于特征的内部化因素之间的相关性.
主要成果:
- 基因组分析显示,诊断和基于特征的内部化因素之间存在很高的遗传相关性 (r_g = .79).
- 双胞胎/收养研究证实了强烈的遗传 (r_g = .76) 和非共享的环境 (r_e = .80) 重叠.
- 对于这两个因素,共同的环境影响是可以忽略不计的,这表明主要是遗传和独特的环境贡献.
结论:
- 这些发现支持当前的精神病理学框架,表明内化诊断和特征之间存在大量重叠.
- 独特的遗传影响可能会使内部化诊断与特征测量有所区别.
- 特征测量可能会受到诊断因素无法捕捉的非添加性遗传效应的影响.
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