氧化基因视网膜病变及其亚型的危险因素
April M Jorge1,2, Ronald B Melles3, Michael F Marmor4
1Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston.
JAMA network open
|May 9, 2024
概括
随着年龄,女性性别,CKD和他莫西芬使用,氧化视网膜病变的风险会增加. 年龄较小和男性性别与较低的风险有关. 种族和民族影响视网膜病变模式.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化是治疗自身免疫性疾病的常见药物.
- 视网膜病变是氧化的一个主要毒性作用.
- 目前的指导方针建议剂量限制和每年对视网膜病变进行查.
研究的目的:
- 为了确定超出剂量和持续时间的氧化网膜病变的危险因素.
- 为个性化氧化治疗和监测策略提供信息.
主要方法:
- 在15年内对4677名患者进行了队列研究.
- 分析了风险因素,包括年龄,性别,种族,并发症和同时服用的药物.
- 多变量Cox比例危险回归评估的视网膜病变风险.
主要成果:
- 年龄较大,女性性别,慢性病 (CKD) 阶段3+和他莫西芬使用与视网膜病变风险增加有关.
- 年龄较小 (<45岁) 和男性性别与较低的风险相关.
- 与非西班牙裔白人患者相比,亚裔和黑人患者患心周视网膜病变的可能性更高.
结论:
- 个体患者的因素显著影响氧化氨酸视网膜病变的风险.
- 年龄,性别,CKD,他莫西芬使用,种族/民族在氧化管理中应考虑.
- 个性化风险评估可以优化患者安全和治疗结果.
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