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精密结直肠癌便免疫学测试查便-血红蛋白-度引导间隔间隔查间隔

Amy Ming-Fang Yen¹, Chen-Yang Hsu^2,3, Ting-Yu Lin³

¹School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

|May 9, 2024

概括

个性化便血红蛋白 (f-Hb) 查间隔可以显著减少FIT测试和结肠镜检查. 这种精确的方法保持了结直肠癌查的有效性,同时优化了资源使用.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
公共卫生公共卫生

背景情况:

便中的血红蛋白 (f-Hb) 度与结直肠瘤风险相关.
f-Hb引导的查间隔正在引起人们的注意,以优化基于人口的便免疫学测试 (FIT).
实施精确策略以节省FIT和结肠镜使用至关重要.

研究的目的:

为了证明个性化结肠直肠癌 (CRC) 查的适用性,使用f-Hb引导间隔.
减少FIT和结肠镜的数量,同时保持查效率.
为了比较资源利用率与普遍的两年一次选.

主要方法:

这是一项回顾性队列研究,使用了台湾两年一次的FIT查计划 (2004-2014) 中超过300万参与者的数据.
普森回归模型以确定基于同等CRC结果有效性的f-Hb引导间隔.
在个性化和普遍查组之间对FIT和结肠镜使用的比较分析.

主要成果:

基线f-Hb的逐渐增加与结直肠瘤和CRC死亡率有关.
参与者根据f-Hb水平被分为风险类别,并推量身定制的查间隔.
与每两年一次的查相比,f-Hb引导的个性化方法减少了49%的FIT测试和28%的结肠镜检查.

结论:

根据f-Hb水平指导的个性化FIT查间隔可以根据新生病和死亡率的梯度关系来制定.
这种精度策略减少了FIT测试和结肠镜检查的使用.
f-Hb引导的间隔保持了普遍两年一次查的有效性,同时优化了资源分配.

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