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选择性CAR T细胞介导的B细胞枯竭抑制了SLE中的IFN签名

Artur Wilhelm1,2, David Chambers1,2, Fabian Müller2,3

  • 1Department of Internal Medicine 3 - Rheumatology and Immunology, FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.

JCI insight
|May 9, 2024
PubMed
概括

向的CD19CAR T细胞治疗有效地重置了系统性红斑狼 (SLE) 中的B细胞反应. 这种方法还减少了单细胞和T细胞中的I型干扰素信号传递,揭示了SLE病变的因果关系.

关键词:
自身免疫性疾病是一种自身免疫性疾病.这是一种自身免疫力.生物信息学是一种生物信息学.免疫学 免疫学 免疫学

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...