纳米塑料与生物系统之间的界面相互作用:向塑料驱动的生物双体平衡的原子和分子理解
Afroz Karim1, Anju Yadav1, Ummy Habiba Sweety2
1Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
ACS applied materials & interfaces
|May 9, 2024
概括
聚乙烯纳米颗粒 (NP) 破坏了像β-乳糖球蛋白这样的蛋白质结构,破坏了营养物质的结合,加速了粉样蛋白的形成. 虫暴露导致神经元缺陷,揭示了微塑料对健康的潜在风险.
科学领域:
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 微型和纳米塑料 (NP) 是人类组织中普遍存在的环境污染物.
- 新出现的证据将NP暴露与不良健康结果联系起来,但基本的分子机制尚不清楚.
- NP与生物分子之间的界面相互作用需要进一步研究.
研究的目的:
- 研究聚钢 (PS) NP对生物分子系统和组件的影响.
- 阐明PSNP影响蛋白质结构,功能和生物过程的机制.
- 探索NP诱导的神经毒性和粉样蛋白形成.
主要方法:
- 在体外实验中使用β-乳糖球蛋白 (BLG) 和蛋白的lyszyme.
- 在体内研究中,使用暴露于PS NPs的C. elegans (C. elegans) 暴露于PS NPs.
- 在形计算分析 (对接和结合能量的计算).
主要成果:
- 根据剂量,PS NPs在BLG中取消了螺旋体含量,促进了β片的形成并降低了视网醇的结合亲和力.
- 在lyszyme中,PS NPs加速了粉样纤维的形成,并在C. elegans中降低了神经元功能和运动.
- 在分析中,在视网结合部位附近发现了有利的PS/BLG相互作用,破坏了视网结合的稳定性.
结论:
- 通过诱导形状变化和损害连接体结合,PSNP破坏蛋白质结构和功能.
- 暴露于NP可以促进粉样粉症并诱导神经元损伤,从而导致异常的生理结果.
- 这些发现提供了对聚乙烯纳米和微塑料对健康的不利影响的机制性见解.
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