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血血红蛋白平均度与高血压患者的死亡率之间的关系:基于人口的队列研究
Dan Li1, Qing Zhang2, Zhishen Ruan1
1The First Clinical College, Shandong Chinese Medical University, Jinan, People's Republic of China.
PloS one
|May 9, 2024
概括
低平均体质血红蛋白度 (MCHC) 与高血压患者的死亡率增加有关. 这一发现凸显了MCHC作为该人群中心血管结果的潜在预后指标.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 血液学在评估心血管疾病 (CVD) 的预后结果方面发挥着至关重要的作用.
- 新兴研究表明,体内平均血红蛋白度 (MCHC) 与各种心血管疾病的预后不佳有关.
- 之前没有证据将MCHC与高血压联系在一起,需要进一步调查.
研究的目的:
- 调查MCHC与高血压患者全因和心血管死亡率之间的关联.
- 为了确定MCHC是否作为高血压患者的预后标志物.
- 在一个大群体中探索MCHC水平和死亡风险之间的关系.
主要方法:
- 利用美国成年人的队列数据在国家健康和营养检查调查 (1999-2014).
- 采用COX回归分析来检查MCHC和死亡结果之间的关系.
- 调整以考虑混因素,并使用倾向性得分匹配 (PSM) 来实现结果的稳定性.
主要成果:
- 包括15,154名高血压患者,平均随访时间为129个月;30.6%的人死亡率.
- 患有低MCHC (低染色体组,≤33mg/dl) 的患者在PSM后表现出更高的全因死亡率 (aHR:1.26) 和心血管死亡率 (aHR:1.42).
- 在PSM后,COX回归结果保持稳定,PSM前分析显示了贫血和MCHC之间的相互作用.
结论:
- 低MCHC与高血压患者的预后不佳显著相关.
- MCHC可能代表高血压不良结果的新预后指标.
- 需要进一步的研究,以阐明MCHC与高血压患者预后不佳相关的潜在机制.
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