埃塞俄比亚中部儿童结核病发展的决定因素:一项匹配的病例控制研究
Abay Burusie1,2, Fikre Enquesilassie2, Nicole Salazar-Austin3
1Department of Public Health, College of Health Sciences, Arsi University, Asella, Ethiopia.
PloS one
|May 9, 2024
概括
埃塞俄比亚儿童的结核病 (TB) 风险因素尚未得到充分研究. 接种BCG疫苗,家庭结核病接触,家庭吸烟和艾滋病毒感染是儿童结核病发展的关键决定因素.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 儿童结核病 (TB) 风险因素仍未得到充分研究,特别是在埃塞俄比亚等低收入地区.
- 确定这些决定因素对于有效的预防和控制策略至关重要.
研究的目的:
- 确定埃塞俄比亚中部儿童结核病发展的决定因素.
- 专门调查BCG疫苗接种与结核病发展有关的作用.
主要方法:
- 在亚的斯亚贝巴,亚达马和比索夫图进行了1:1年龄相匹配的病例控制研究.
- 招募了256名患有结核病的儿童 (病例) 和256名对照儿童.
- 使用双变量和多变量条件逻辑回归分析来确定独立的决定因素.
主要成果:
- 未接种BCG疫苗的儿童患结核病的几率是其两倍以上 (mORadj = 2.11).
- 家庭结核病接触 (mORadj = 4.28),家庭吸烟暴露 (mORadj = 3.15) 和艾滋病毒感染 (mORadj = 8.71) 显著增加了结核病的几率.
- 病例的平均年龄为9岁,对照组为10岁;男性在两组中都占主导地位.
结论:
- BCG疫苗接种状态是儿童结核病发展的一个重要因素.
- 家庭结核病接触,吸烟和艾滋病毒感染是儿童结核病的独立危险因素.
- 这些发现突出了针对埃塞俄比亚儿童的有针对性的干预措施的关键领域.
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