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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Phylogenetic Trees03:21

Phylogenetic Trees

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Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
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Synteny and Evolution02:31

Synteny and Evolution

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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
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Phylogeny01:23

Phylogeny

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Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
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Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
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斯库弗:为细胞谱系树重建提供了一个概率框架.

Hazal Koptagel1,2, Seong-Hwan Jun3, Joanna Hård4

  • 1School of EECS, KTH Royal Institute of Technology, Stockholm, Sweden.

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斯库弗利用DNA测序数据重建细胞谱系树,提供更快,更准确的分析. 该方法解决了用于发育和癌症研究的单细胞测序的常见挑战.

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科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 发展生物学 发展生物学

背景情况:

  • 细胞谱系树的重建对于理解发育,分化和癌症至关重要.
  • 单细胞测序技术为细胞过程提供了高分辨率的洞察力.
  • 现有的方法在复杂的生物系统中面临着噪音和准确性的挑战.

研究的目的:

  • 介绍Scuphr,一种用于细胞谱系树重建的新型计算方法.
  • 为了提高准确性,利用大量和单细胞DNA测序数据.
  • 解决和纳入单细胞DNA测序数据中常见的错误.

主要方法:

  • Scuphr采用基于距离的方法来推断细胞之间的关系.
  • 它使用邻居连接算法来重建遗传树.
  • 该方法包括处理单细胞DNA测序固有的等位基脱落和放大错误.

主要成果:

  • 由于其并行设计,Scuphr与最先进的方法相比可以进行更快的分析.
  • 该方法在重建细胞系谱树方面实现了更高的准确性.
  • 使用多种合成数据集和18个细胞的生物数据集验证了强度.

结论:

  • 斯库弗提供了一个高效和准确的解决方案,用于细胞谱系树的重建.
  • 该方法强大,能够应对单细胞DNA测序中的技术挑战.
  • Scuphr利用基因组数据推进了细胞发育和疾病进展的分析.