内源性雌激素暴露和高血压风险;基于人口的队列研究,约20年的随访
Fahimeh Ramezani Tehrani1, Maryam Mousavi1, Marzieh Saei Ghare Naz1
1Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran.
概括
较长的内源性雌激素暴露 (EEE) 显著降低了女性高血压 (HTN) 的风险. 这种保护作用甚至在患有高血压前期的女性中也被观察到,突出显示了EEE.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 妇女健康 妇女健康
背景情况:
- 内源性雌激素暴露 (EEE) 和高血压 (HTN) 发生率之间的关系仍未得到充分研究.
- 了解这种联系对于女性心血管健康管理至关重要.
研究的目的:
- 根据内源性雌激素暴露的不同持续时间,评估女性高血压的发生率.
- 为了确定长时间的EEE是否会影响高血压风险.
主要方法:
- 利用了来自德黑兰脂质和葡萄糖研究的数据,其中包括4463名经期正常压力女性.
- 计算了每个参与者的EEE,并使用Cox回归模型跟踪高血压事件.
- 分析了与EEE z-score相关的HTN发生率的危险比率和置信区间.
主要成果:
- 经过更长时间的EEE与绝经后妇女的高血压发病率相反相关.
- 在EEE z-score中每增加1个SD,不调整的HTN风险降低了53% (HR 0.47),调整的HTN风险降低了54% (HR 0.46).
- 在基线前患有高血压前期的女性显示,每1SD增加EEEz-score,患高血压的风险降低了56%.
结论:
- 长时间内源性雌激素暴露表明,对高血压的发展有显著的保护作用.
- 这种保护性关联甚至适用于患有高血压前期的女性,这表明EEE的潜在预防作用.
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