一个定制的生物混合体,呈现对瘤微环境的级联反应
Feiyu Li1,2, Peipei Zhu1,2, Bingzhu Zheng1,2
1State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Advanced materials (Deerfield Beach, Fla.)
|May 9, 2024
概括
工程细菌和纳米粒子创造了一个生物混合物,用于精确的瘤切除. 这种向治疗利用特定的代谢途径来消除癌细胞并抑制瘤生长和转移.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 微生物学 微生物学
背景情况:
- 微生物在医学使用中面临着由于新陈代谢,副产品和繁殖的限制.
- 向性瘤治疗需要精确的癌细胞破坏机制.
研究的目的:
- 设计一种生物混合系统,以高效地准癌症部位和精确地切除瘤.
- 使用预先确定的代谢途径,以提高治疗结果.
主要方法:
- 工程 DH5α 埃舍里希亚大肠杆菌与缺氧诱导促进体和乳酸氧化酶基因.
- 表面装甲的细菌与铁ZIF-8纳米粒子.
- 利用纳米颗粒的类似过氧化酶的活性产生细胞毒性基.
主要成果:
- 改造的大肠杆菌在低氧瘤环境中产生乳酸氧化酶,减少乳酸.
- 纳米粒子将过氧化转化为基基,诱导铁灭.
- 生物混合物在静脉注射后显著抑制瘤生长和转移.
结论:
- 开发的生物混合体为向瘤治疗提供了一个新的策略.
- 这种方法克服了传统基于微生物的治疗方法的局限性.
- 该工程系统显示出强大的抗瘤疗效和临床转化潜力.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Tumor Immunotherapy
518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
518
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:19Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K