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相关概念视频

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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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相关实验视频

Updated: Jun 26, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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在怀孕前的夫妇中,甲酸盐暴露和次生育能力:一项嵌套病例控制研究.

Anxin Yin1, Lisha Mao2, Congcong Zhang1

  • 1Department of Maternal, Child and Child Health, School of Public Health, Fudan University, Key Laboratory of Health Technology Evaluation (National Health Commission), Fudan University, Shanghai 200032, China.

Ecotoxicology and environmental safety
|May 9, 2024
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概括

暴露于常见的内分泌干扰物甲酸盐 (PAE) 显著增加试图怀孕的夫妇的子孕症风险. 监测PAE暴露对于改善生殖健康至关重要.

关键词:
嵌套病例控制研究研究.甲酸是一种甲酸.预先设想的情侣 预先设想的情侣下属性 副次性 副次性怀孕的时间到怀孕.

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科学领域:

  • 环境健康 环境健康
  • 生殖毒理学 生殖毒理学
  • 内分泌学 在内分泌学.

背景情况:

  • 酸盐 (PAE) 是广泛存在的内分泌干扰化学物质.
  • 对PAE环境暴露是一个全球性问题.
  • 副生育性影响试图怀孕的夫妇.

研究的目的:

  • 为了调查甲酸盐 (PAE) 暴露和预孕夫妇的子育能力之间的关联.
  • 评估PAE混合暴露对生殖健康的联合影响.

主要方法:

  • 嵌套的病例控制研究在一个预先概念队列内.
  • 在107对子育和144对子育夫妇的尿甲酸代谢物水平分析.
  • 应用加权量子总和 (WQS) 和贝叶斯核机器回归 (BKMR) 模型.

主要成果:

  • 尿甲酸度较高与女性和男性分娩后分娩风险增加有关.
  • 观察到甲酸盐暴露和亚产性之间的剂量反应关系.
  • 对甲酸盐混合物的联合暴露显著增加了个人和夫妇的次生育风险.

结论:

  • 甲酸盐暴露是孕前夫妇次生育的重要危险因素.
  • 建议减少环境甲酸盐的暴露,以提高人类的生殖健康.
  • 进一步监测PAE暴露对于公共卫生倡议至关重要.