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在T₁加权旋转回声上的灰白质对比逆转在死后的大脑中

Masatoshi Kojima¹, Yohsuke Makino², Rutsuko Yamaguchi³

¹Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan; Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Forensic science international

|May 9, 2024

概括

尸体后MRI显示白色和灰色物质之间的对比度因质子密度下降而逆转. 这一发现澄清了死后脑部扫描中图像对比度改变的原因.

科学领域:

放射学放射学是一门学科.
神经科学是一个神经科学.
法医科学法医科学法医科学

背景情况:

由于生理变化和扫描条件,死后MRI对比度不同于死前MRI.
灰质 (GM) 和白质 (WM) 的对比度在与活体相比的死后T1加权旋回回声 (T1WSE) 图像中是逆转的.
在死后大脑中发生这种GM-WM对比逆转的根本原因尚不清楚.

研究的目的:

为了调查和澄清死后大脑MRI中观察到的GM和WM之间的对比逆转背后的原因.
确定导致死后脑组织信号强度变化的关键因素.

主要方法:

死后T1W-SE脑部MRI用1.5TMRI系统对23具尸体进行.
测量了GM和WM的T1和T2放松时间,以及质子密度 (PD) 在基底腺区域.
在法医解剖之前,测量是在低体温 (平均6.9°C) 进行的.

主要成果:

所有死后的大脑都在T1W-SE图像上显示了与活大脑相比的反向GM-WM对比.
在GM和WM死后,T1放松时间都减少了,WM/GM比率仍然低于1.
质子密度 (PD) 在GM和WM死后显著下降,WM/GM比率显著下降. T2值与活大脑没有显著差异.

结论:

灰色和白质的质子密度 (PD) 显著下降被认为是导致死后脑MRI观察到的对比率逆转的主要因素.
了解这些变化对于准确解释死后神经成像发现至关重要.

关键词:

脑子脑子脑子脑子尸体验验后的MRI图像显示了死亡的情况.验尸后的变化死亡后的成像检查虚拟尸检是虚拟的尸检.

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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...