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老年人深度大脑刺激后的结果与帕金森病的非老年患者相比
Yilong Zheng1, Li Wei2, Samantha Ya Lyn Ang3
1SingHealth PGY1 Program, Singapore General Hospital, Singapore.
Clinical neurology and neurosurgery
|May 9, 2024
概括
接受深度大脑刺激 (DBS) 的老年帕金森病患者表现出与年轻患者相似的运动改善和药物减少. 仅仅是年龄不应该使患者无法获得DBS,强调个性化治疗决策.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
背景情况:
- 深度大脑刺激 (DBS) 是对帕金森病 (PD) 的治疗方法.
- 老年患者可能面临更高的风险和DBS的不确定的好处.
- 在老年PD患者中评估DBS结果至关重要.
研究的目的:
- 为了比较DBS在老年人 (≥70岁) 与非老年人 (<70岁) 帕金森病患者的有效性和安全性.
主要方法:
- 对机构队列的分析和对公共数据的系统审查.
- 运动功能的比较 (MDS-UPDRS/UPDRS第三部分),药物剂量 (LEDD) 和不同年龄组的不良事件.
- 在DBS电极插入时,将老年人定义为≥70岁,非老年人定义为<70岁.
主要成果:
- 在老年人和非老年患者之间,在运动得分改善或LEDD减少方面没有显著差异.
- 老年患者表现出较高的伤口感染率和不良愈合率的非显著趋势.
- 年龄组之间死亡率,中风或认知衰退没有显著差异.
结论:
- 老年患者获得了与非老年患者相似的PDDBS的运动结果和药物效益.
- 年龄不应该是对帕金森病的DBS资格的唯一因素.
- 建议对老年DBS候选人进行个性化,多学科的评估.
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