中年和老年人的粮食不安全和表观遗传衰老
Javier A Tamargo1, Yenisel Cruz-Almeida1
1Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Institute on Aging, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL, USA.
Social science & medicine (1982)
|May 9, 2024
概括
粮食不安全性通过改变DNA甲基化模式,加速了老年人的生物衰老. 这项研究强调了社会经济因素如何在分子层面影响健康和衰老.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 粮食不安全是老年人健康的重要社会决定因素.
- 虽然与发病率和死亡率有关,但其在加速生物衰老中的作用不太清楚.
- 表观遗传改变是将粮食不安全与衰老联系起来的潜在机制.
研究的目的:
- 调查粮食不安全和表观遗传衰老之间的关系.
- 评估表观遗传衰老作为中年和老年人生物衰老的衡量标准.
- 在美国全国代表性样本中检查这一关联.
主要方法:
- 从2016年健康和退休研究 (HRS) 中对3875名50岁以上的成年人进行横截面分析.
- 通过自我报告问题评估金融粮食不安全.
- 用基于DNA甲基化的表观遗传钟来测量表观遗传衰老 (例如,张,PhenoAge,GrimAge,DunedinPoAm).
- 对生物学,社会经济和行为因素进行调整的线性回归.
主要成果:
- 8.1%的参与者报告粮食不安全.
- 粮食不安全与年龄较小,少数群体地位较低,收入/财富较低,教育程度较低,BMI较高和体力活动较少有关.
- 粮食不安全与多个表观遗传时钟的加速表观遗传衰老显著相关,包括张和GrimAge,即使在完全调整后.
结论:
- 粮食不安全与美国中年和老年人加速表观遗传衰老有关.
- 这表明,粮食不安全可能导致DNA甲基化变化和生物衰老加速.
- 研究结果强调了社会经济地位对表观基因组和衰老健康的影响.
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