在IgA病中,肠道损伤的间接标志物
Jussi Pohjonen1,2, Katri Kaukinen1,2, Heini Huhtala3
1Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
在IgA脏病 (IgAN) 患者中肠道脂肪酸结合蛋白 (I-FABP) 水平升高表明亚临床肠道损伤. 这一发现突出了肠道.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 亚临床肠道炎症在IgA脏病 (IgAN) 中很常见.
- 在IGAN中的组织学炎症与尿路异常相关.
- 在IGAN中缺乏肠道损伤的非侵入性生物标志物.
研究的目的:
- 调查Igan患者肠道损伤的间接标志物是否升高.
- 在IGAN中识别潜在的亚临床肠损伤的非侵入性生物标志物.
主要方法:
- 该研究包括85名Igan患者,14名腹控制组和15名健康控制组.
- 排除乳病和炎症性肠道疾病.
- 对肠道脂肪酸结合蛋白 (I-FABP),可溶性CD14 (sCD14) 和脂多糖结合蛋白的血清分析.
主要成果:
- 在I-FABP患者中,I-FABP水平明显高于健康对照患者 (p < 0.001).
- 与腹控制组相比,IgAN患者的sCD14水平增加.
- 血清转胺酶2抗体 (TG2Ab) 水平在IgAN患者中比健康对照中高 (p < 0.001).
结论:
- 血清I-FABP升高表明IGAN患者潜在的亚临床肠损伤.
- I-FABP可以作为IgAN中肠道参与的非侵入性生物标志物.
- 需要进一步的研究来探索肠道在IGAN病理生理学中的作用.
更多相关视频
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
07:05Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
