制造用于促进生物活性的硫乙-β-环氧化/格拉布里丁含有复合物的制造
Wanru Wang1, Kewen Tang1, Chenggang Huang2
1Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, China.
Archiv der Pharmazie
|May 9, 2024
概括
格拉布里丁 (GLD) 的溶解性问题通过将其封装在硫乙烯-β-环氧化 (SBE-β-CD) 复合体中来克服. 这种SBE-β-CD/GLD配方增强了GLD.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 格拉布里丁 (GLD) 是来自Glycyrrhiza glabra L.的关键化合物,具有多样化的生物活性,但由于水溶性差,临床应用有限.
- 开发有效的药物输送系统对于增强GLD的治疗潜力至关重要.
研究的目的:
- 通过冷干燥将GLD封装成基于硫乙烯-β-环氧化 (SBE-β-CD) 的包容复合物 (SBE-β-CD/GLD).
- 评估SBE-β-CD/GLD复合物的表征,生物相容性,抗菌活性,抗氧化能力和体内伤口愈合疗效.
主要方法:
- 用冷干燥方法制造SBE-β-CD/GLD纳入复合体.
- 使用UV-Vis光谱,FT-IR,XRD,SEM和NMR进行材料表征.
- 在体外评估抗菌活性,细胞行为 (HUVEC,红细胞) 和抗氧化活性.
- 在临床前模型中对糖尿病病人的全厚伤口愈合的体内评估.
主要成果:
- 通过多种分析技术证实了SBE-β-CD/GLD纳入复合物的成功形成和表征.
- 显著提高了SBE-β-CD/GLD与人血管内皮细胞和红细胞的水溶性和出色的生物相容性.
- 显著的体外抗菌活性针对金黄色葡萄球菌和大肠杆菌.
- 显著增强抗氧化活性,并通过抑制炎症,强烈加快全厚皮肤缺陷的愈合.
结论:
- SBE-β-CD有效地提高了GLD的水溶性和生物相容性,形成了一个稳定的包容复合体.
- 该SBE-β-CD/GLD复合体显示出显著的抗菌,抗氧化和伤口愈合特性.
- SBE-β-CD作为一种有前途的药物输送系统,用于GLD的临床翻译.
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