儿童癌症幸存者:当前的挑战
1Hospital Universitario Materno Infantil Princesa Leonor, Almería, Spain.
Anales de pediatria
|May 9, 2024
概括
儿童癌症幸存者 (CCS) 面临着显著的长期健康风险. 改善长期随访 (LTFU) 对于管理晚期影响和提高这些幸存者的生活质量至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 公共卫生 公共卫生
- 幸存者研究研究 幸存者研究
背景情况:
- 在发达国家,儿童癌症的生存率超过80-85%,导致儿童癌症幸存者 (CCS) 人口不断增加.
- 由于癌症及其治疗,CCS患病率和死亡率很高,包括过早死亡,二次瘤和身体/心理社会后期影响,降低生活质量.
- 为预防,检测和管理这些健康问题,建议对CCS进行长期随访 (LTFU),但目前的管理仍然不够理想.
研究的目的:
- 确定改善儿童癌症幸存者的管理和长期随访 (LTFU) 的关键领域.
- 讨论用于量化疾病死亡负担和评估个体风险的新方法.
- 探索影响晚期副作用的因素,以及在实施协调,个性化的LTFU战略时面临的挑战.
主要方法:
- 审查和讨论当前的挑战和建议的改进LTFU的CCS.
- 探索新的频率指标 (累计平均计数,累计负担) 和风险评估的模拟模型.
- 对延迟效应的风险因素的分析以及国际指导方针协调对LTFU的影响.
主要成果:
- 目前对CCS的管理不是最佳的,需要改进LTFU策略.
- 通过新的措施和模拟模型量化疾病死亡负担,可以提供更准确的风险评估.
- 了解晚期影响的风险因素和协调LTFU指南对于基于证据的个性化护理至关重要.
结论:
- 优化CCS的LTFU需要更好地量化健康负担,评估风险因素,和国际协调指南.
- 实施适应风险的护理模式和解决向成人护理的过渡是有效LTFU的关键挑战.
- 未来的前景重点是改善CCS患者的健康和生活质量,并特别考虑西班牙的情况.
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancer Vaccines
358
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
358


