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相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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通过超临界抗溶剂工艺生产的PVP/aprepitant微.

Zhuo Zhang1, Guizhou Hao2, Xuemei Sun1

  • 1College of Mechanical and Vehicle Engineering, Linyi University, Linyi, 276000, China.

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概括
此摘要是机器生成的。

超临界抗溶剂 (SAS) 工艺为制造药物微囊提供了一种绿色方法,改善药物溶解. 这项研究展示了SAS的流程.

关键词:
这是一种阿普雷皮坦特 (Aprepitant).同轴环状喷嘴,同轴环状喷嘴.工业化的工业化微囊中的微囊超临界抗溶剂工艺的超临界抗溶剂工艺.

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科学领域:

  • 制药技术 制药技术 制药技术
  • 绿色化学 绿色化学
  • 材料科学 材料科学 材料科学

背景情况:

  • 不溶性药物往往具有较差的生物可用性,限制了它们的治疗效果.
  • 超临界抗溶剂 (SAS) 工艺提供了一种可持续的方法来提高药物的溶解性和输送.
  • 由于产能限制,扩大SAS工艺用于工业制药生产仍然是一个挑战.

研究的目的:

  • 使用SAS工艺与聚烯利 (PVP) 开发阿普雷匹坦 (APR) 的微囊.
  • 调查工艺参数对微囊特性的影响.
  • 评估用于制药制造的SAS工艺的工业可扩展性.

主要方法:

  • 一个同轴环状喷嘴被用于通过SAS使用N,N-Dimethylformamide (DMF) 来微封装阿普里坦 (APR) 和聚烯 (PVP).
  • 对聚合物/药物比率,工作压力,温度和度对粒子形态,大小和分布的影响进行系统分析.
  • 微囊的特征包括形态,颗粒大小,热行为,结晶性,药物含量,溶解和残留溶剂.

主要成果:

  • 成功生产了平均直径在2.04微米至9.84微米之间的微囊.
  • 优化的SAS过程参数导致了粒子特性和形态的改进.
  • 与未经加工的APR相比,APR微囊的溶解率有所提高.
  • 证明了千克级生产能力,证实了工业可行性.

结论:

  • 采用同轴环状喷嘴的SAS工艺,有效生产具有增强溶解的阿布雷皮坦微囊.
  • 优化过程参数对于控制微囊特性至关重要.
  • 该研究验证了SAS制药生产工艺的工业可扩展性,解决了以前的产能限制.