中央行政网络调节创伤后压力症状严重程度和胃肠道相关问题之间的关系
Kia A Howard1, Salman S Ahmad1, Jennifer V Chavez2
1Department of Psychology, University of Miami, Coral Gables, FL, 33146, USA.
Scientific reports
|May 9, 2024
概括
亚临床创伤后应激 (PTS) 症状与胃肠道 (GI) 问题相关. 然而,强大的中央执行网络 (CEN) 功能连接可能会缓冲这种关联,这表明执行控制在缓解GI问题方面发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 大多数成年人经历过创伤,但很少有人患上创伤后应激障碍 (PTSD).
- 创伤后应激障碍与胃肠道 (GI) 疾病风险增加有关.
- 亚临床创伤后应激 (PTS) 和胃肠道问题之间的联系尚不清楚.
研究的目的:
- 调查亚临床PTS症状严重程度与肠道问题的数量之间的关系.
- 检查中央执行网络 (CEN) 的静止状态功能连接 (rsFC) 是否缓解了PTS-GI症状联系.
主要方法:
- 利用休息状态的fMRI,病史,心理调查和378名成年人 (18-85.6岁) 的人类学数据.
- 使用创伤症状检查清单-40 (TSC-40) 评估PTS症状严重程度.
- 在CEN中分析了rsFC及其与TSC-40在地理标识问题上的评分的相互作用,控制共变量.
主要成果:
- 较高的PTS症状严重程度 (TSC-40分数) 与更多的经认可的胃肠道问题显著相关.
- 发现了显著的相互作用:CEN内的高于平均水平的rsFC缓冲了PTS症状严重程度和胃肠道问题的关联.
结论:
- 亚临床PTS症状与一般人口样本中的胃肠道问题有关.
- 增强的CEN功能连接可能会减轻PTS症状对肠道健康的影响,可能是通过影响肠道失调的执行控制机制.
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