哈尔科莫拉辛在肝细胞癌细胞中促进了亡和内细胞网膜应激
Yongliang Cui1, Liqin Lan2, Jiahui Lv1
1Department of Hepatobiliary Pancreatic Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350028, China.
The Journal of antibiotics
|May 9, 2024
概括
哈尔科莫拉辛 (CMR) 通过诱导亡和ER压力来抑制肝细胞癌 (HCC) 的生长. 这种天然化合物还通过抑制MAPK通路来抑制瘤进展,显示出作为抗癌治疗的潜力.
科学领域:
- 自然产品 化学 化学
- 癌症生物学 癌症生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 哈尔科莫拉辛 (CMR) 是一种来自木叶的化合物,具有广泛的抗癌特性.
- 肝细胞癌 (HCC) 仍然是一个重大的全球健康挑战,需要新的治疗策略.
研究的目的:
- 调查尔科莫拉 (CMR) 在肝细胞癌 (HCC) 的功能作用和潜在机制.
- 评估CMR作为HCC治疗的抗癌剂的潜力.
主要方法:
- 在体外研究中,使用HCC细胞系 (Hep3B,SNU-387) 用不同的CMR度治疗.
- 评估细胞活力,殖民地形成,细胞亡,迁移和入侵.
- 西部斑点分析内质网膜 (ER) 应激和线粒激活蛋白激酶 (MAPK) 途径蛋白.
- 在体内实验中评估CMR对HCC瘤生长的影响.
主要成果:
- CMR显著抑制了HCC细胞活力,殖民地形成,迁移和入侵.
- CMR治疗促进了HCC细胞的亡和诱导ER压力.
- 在HCC中,CMR降低了关键MAPK通路蛋白 (ERK,P38,JNK) 的酸化.
- 在体内研究证实了CMR能够抑制HCC中的瘤发生和MAPK通路活性.
结论:
- 哈尔科莫拉辛 (CMR) 在体外和体内表现出强大的抗癌作用,对肝细胞癌 (HCC) 具有强烈的抗癌作用.
- CMR通过诱导亡,ER压力和抑制MAPK信号通路来发挥其作用.
- 作为HCC治疗的潜在治疗剂,CMR具有前景.
相关概念视频
01:31The Intrinsic Apoptotic Pathway
6.5K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.5K
01:30Apoptosis
11.4K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.4K
01:31Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
01:17The Extrinsic Apoptotic Pathway
6.3K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K