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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Percutaneous Native Kidney Biopsy Complications in Diabetic Patients in the TRIDENT Cohort.

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Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
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细胞向疗法 - - 进展和未来的方向

Kristin Meliambro1, John C He1, Kirk N Campbell2

  • 1Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nature reviews. Nephrology
|May 9, 2024
PubMed
概括

足细胞损伤导致蛋白尿性脏疾病,导致功能衰竭. 近期了解细胞病变的进展为超越当前免疫抑制剂的新精密疗法提供了希望.

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 细胞是蛋白尿性脏疾病的关键细胞,是衰竭的主要原因.
  • 在渐进的淋巴细胞疾病中,已确立细胞枯竭和蛋白尿严重程度之间的联系.
  • 目前的 podocytopathies 治疗方法主要使用重新设计的免疫抑制药物,但成功程度有限.

研究的目的:

  • 审查了解细胞损伤机制的最新进展.
  • 为突出球细胞疾病的新兴治疗策略.
  • 讨论精准医学的潜力,在治疗podocytopathies.

主要方法:

  • 关于开创性的实验和临床研究的审查.
  • 在 podocytopathies 的遗传发现的分析.
  • 评估新的治疗目标和再生方法.

主要成果:

  • 识别了许多引起疾病的基因和质透性因素.
  • 了解细胞损伤的机械基础的进展.
  • 使用原生细胞开发潜在的再生策略.

结论:

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  • 在了解细胞损伤方面取得的重大进展为精密疗法开辟了道路.
  • 新的目标,再生方法和药物输送系统为淋巴细胞疾病治疗提供了乐观的未来.
  • 未来的疗法可能会超越目前的免疫抑制疗法.