对T1b食道癌进行内镜下膜剖析与手术:单中心回顾性研究
Ting Zhang1, Hanying Wang1, Tian Jin1
1Department of Endoscopy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.
Journal of cancer research and clinical oncology
|May 9, 2024
概括
内镜下粘膜切割 (ESD) 显示,与T1b食道状细胞癌 (SESCC) 手术的长期存活率相似,并发症率较低. 对于pT1b-SM2病例,需要进一步的随访.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 内镜下粘膜切割 (ESD) 是表面食道状细胞癌 (SESCC) 的首要治疗方法.
- 有限的数据存在,比较ESD和T1b SESCC手术之间的长期存活率.
- 本研究通过评估生存结果和并发症来解决这一差距.
研究的目的:
- 为了比较T1b SESCC的ESD和手术之间的总生存率 (OS),无疾病生存率 (DSS) 和无复发生存率 (RFS).
- 评估与每种治疗方式相关的并发症率和住院时间.
- 为了确定T1b SESCC患者复发的风险因素.
主要方法:
- 对于T1b SESCC (2009-2021) 的47个ESD和73个手术病例的回顾性审查.
- 根据瘤侵袭深度和年龄 (老年患者) 进行了子组分析.
- 卡普兰-梅尔分析和多变量分析用于评估生存和复发风险因素.
主要成果:
- 在ESD和手术组之间没有观察到OS,DSS或RFS的显著差异.
- 与手术相比,ESD与较低的死亡率和复发率有关.
- 查尔森共同发病率指数和下层侵袭深度被确定为复发风险因素.
结论:
- 对于T1b SESCC,ESD提供了与手术相似的长期存活率,并减少了并发症率和更短的住院时间.
- 对于pT1b-SM2患者,持续的长期随访是必不可少的.
- 在某些T1b SESCC病例中,ESD是手术的可行替代方案.
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