肝脏侧状内皮细胞依赖于氧化酸化,但避免在线粒体中处理长链脂肪酸
Patrycja Kaczara1, Izabela Czyzynska-Cichon2, Edyta Kus2
1Jagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET), Bobrzynskiego 14, 30-348, Krakow, Poland. patrycja.kaczara@jcet.eu.
Cellular & molecular biology letters
|May 9, 2024
概括
肝脏的鼻状内皮细胞 (LSECs) 使用氧化酸化,而不仅仅是糖解,以获得能量. 它们有效地代谢各种燃料,但不会在线粒体中直接氧化棕酸.
科学领域:
- 细胞生物学 细胞生物学
- 代谢生物化学 代谢生物化学
- 血管生物学 血管生物学
背景情况:
- 内皮细胞 (ECs) 通常依赖于糖解来产生ATP.
- 肝脏的鼻状内皮细胞 (LSEC) 表现出代谢可塑性.
- 对于LSEC能量代谢的基质利用情况尚不清楚.
研究的目的:
- 描述初级小鼠LSECs的能量代谢.
- 在LSEC中确定ATP生产的基质偏好.
- 调查脂肪酸氧化在LSEC生物能源学中的作用.
主要方法:
- 海马XF分析细胞呼吸.
- 蛋白质组学用于识别代谢酶.
- 对脂肪酸代谢的乙 - 卡尼丁分析和拉曼光谱.
主要成果:
- LSECs依赖于氧化酸化,由葡萄糖,脂肪酸和谷氨酸提供燃料.
- 棕酸不会被LSEC线粒体直接氧化.
- 棕酸通过过氧体氧化间接支持线粒体呼吸.
结论:
- LSECs具有独特的生物能特征,与典型的ECs不同.
- LSECs在代谢上高度适应肝脏的微环境.
- 在LSEC中依赖氧化酸化的情况需要进一步研究.
更多相关视频
相关概念视频
Peroxisomes
12.1K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
12.1K
Liver Histology
738
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
738
Peroxisomes and Mitochondria
87.1K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
87.1K
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Liver Physiology
514
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
514
Hepatic Portal System
1.2K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.2K


