ECM模仿,NSAIDs加载热响应,免疫调节水凝用于类风湿性关节炎治疗
Dipesh Kumar Shah1, Sumanta Ghosh1, Namdev More1
1National Institute of Pharmaceutical Education and Research - Ahmedabad, Opp. Airforce station, Gandhinagar, Gujarat, 382355, India.
BMC biotechnology
|May 9, 2024
概括
这项研究开发了一种可注射的水凝系统,用于类风湿性关节炎 (RA) 治疗. 水凝模仿天然组织,可持续释放NSAID,并显示抗炎作用,为关节炎症提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 类风湿病学 类风湿病学
- 药物输送系统 药物输送系统
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节炎症.
- 传统的RA治疗有局限性,包括毒性和药物输送障碍.
- 开发了一种可注射的水凝系统,以有效地提供NSAIDs用于RA治疗.
研究的目的:
- 开发和评估一种可注射,ECM模拟的水凝,用于关节内药物输送.
- 评估水凝系统的药物释放动力学,生物相容性和抗炎性潜力.
- 为了探索水凝在调节关节内炎症方面的疗效.
主要方法:
- 制造热敏的,ECM模拟的水凝.
- 在水凝系统中加载NSAIDs (二甲).
- 在体外释放药物的研究,DPPH激素清除试验,MTT生物相容性试验,以及对抗炎活性的基因表达分析 (RAW 264.7细胞).
主要成果:
- 水凝表现出模仿自然细胞外基质 (ECM) 的表面形态和多孔性.
- 用NSAID加载的水凝显示24小时的突发释放,随后持续释放长达10天.
- 水凝表现出良好的基因清除活性,生物相容性和关键炎症基因 (COX-2,TNF-α) 的显著下调.
结论:
- 开发的ECM模仿性,热敏的in situ水凝显示出在RA中治疗关节内炎症的潜力.
- 这种系统可以减少药物治疗的频率,并增强关节滑.
- 水凝为克服传统RA疗法的局限性提供了一种有希望的方法.
相关概念视频
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
131
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
131
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
158
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
158